N,N-Dimethylcyclohexanamine

Names

[ CAS No. ]:
98-94-2

[ Name ]:
N,N-Dimethylcyclohexanamine

[Synonym ]:
Cyclohexanamine, N,N-dimethyl-
N,N-Dimethylcyclohexanamine
Dimethylaminocyclohexane
N,N-Dimethyl-1-cyclohexan-1-amine
N,N-Dimethylcyclohexylamine
MFCD00003844
EINECS 202-715-5

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
162.0±8.0 °C at 760 mmHg

[ Melting Point ]:
-60 °C

[ Molecular Formula ]:
C₈H₁₇N

[ Molecular Weight ]:
127.227

[ Flash Point ]:
42.2±0.0 °C

[ Exact Mass ]:
127.136101

[ PSA ]:
3.24000

[ LogP ]:
2.12

[ Vapour Pressure ]:
2.2±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Water Solubility ]:
10 g/L (20 ºC)

[ Freezing Point ]:
<-77℃

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GX1198000

CHEMICAL NAME :: Cyclohexylamine, N,N-dimethyl-

CAS REGISTRY NUMBER :: 98-94-2

BEILSTEIN REFERENCE NO. :: 1919922

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H17-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 348 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1889 mg/m3/2H

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(5),54,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536456

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(5),54,1984

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/m3/2H

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 28(5),54,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2994 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 24 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2994 No. of Facilities: 563 (estimated) No. of Industries: 11 No. of Occupations: 16 No. of Employees: 6130 (estimated) No. of Female Employees: 253 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H311-H314-H330-H400

[ Precautionary Statements ]:
P260-P273-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R10;R22;R23/24;R34

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S61-S28A-S16

[ RIDADR ]:
UN 2264 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
GX1198000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Formaldehyde
Cyclohexylamine
Cyclohexanone
Dimethylamine
N-Methylcyclohexanamine
methyl iodide
N,N-Dimethylaniline
N,N-dimethylcyclohexanamine oxide
Methanol
3-dimethylamino-phenol, hydrochloride

DownStream

2-PYRIMIDINAMINE, N,N-DIMETHYL-
N-cyclohexyl-N-methylpyrimidin-2-amine
2-Methylbenzoic acid
Phthalide
Cyclohexylamine
Bentazon
Methyl 4-chlorobenzoate
1,2-Benzisothiazol-3-amine 1,1-dioxide
N-methyl-9,9-dioxo-9$l^{6}-thia-8-azabicyclo[4.3.0]nona-1,3,5,7-tetraen-7-amine
N-Methylcyclohexanamine

Preparation

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Liquid membrane work-up of blood plasma samples applied to gas chromatographic determination of aliphatic amines.

J. Chromatogr. A. 573(2) , 191-200, (1992)

A technique for sample work-up and enrichment using a supported liquid membrane in an automated flow system, connected to a gas chromatograph, was used for the determination of aliphatic amines in hum...

Switchable hydrophilicity solvents for lipid extraction from microalgae for biofuel production

Bioresour. Technol. 118 , 628-32, (2012)

Highlights ► We extracted lipids from microalgae using switchable hydrophilicity solvents (SHS). ► SHS extractions at room temperature yielded more intact triacylglycerols than at 80°C. ► Extractions ...

Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct alpha-cyanoamination of ketones and aldehydes.

Chem. Commun. (Camb.) (44) , 6839-41, (2009)

The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary ...

N,N-dimethylcyclohexanamine oxide
4-Iodo-N,N-dimethylcyclohexanamine
4-Bromo-N,N-dimethylcyclohexanamine
N,N-dimethylcyclohexanamine,hydrobromide
N,N-DIMETHYLCYCLOHEXANAMINE HYDROCHLORIDE
4,4-dimethoxy-N,N-dimethylcyclohexanamine