Chelidonic acid

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Names

[ CAS No. ]:
99-32-1

[ Name ]:
Chelidonic acid

[Synonym ]:
4-oxopyran-2,6-dicarboxylic acid
EINECS 202-749-0
MFCD00006577

Chemical & Physical Properties

[ Density]:
1.821 g/cm3

[ Boiling Point ]:
471.3ºC at 760 mmHg

[ Melting Point ]:
265 °C (dec.)(lit.)

[ Molecular Formula ]:
C7H4O6

[ Molecular Weight ]:
184.10

[ Flash Point ]:
204.1ºC

[ Exact Mass ]:
184.00100

[ PSA ]:
104.81000

[ LogP ]:
0.03620

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP7350000
CHEMICAL NAME :
4H-Pyran-2,6-dicarboxylic acid, 4-oxo-
CAS REGISTRY NUMBER :
99-32-1
BEILSTEIN REFERENCE NO. :
0163607
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H4-O6
MOLECULAR WEIGHT :
184.11
WISWESSER LINE NOTATION :
T6O DVJ BVQ FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,54,1954

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UP7350000

[ HS Code ]:
2932999099

Synthetic Route

Precursor & DownStream

Precursor

  • Diethyloxalate
  • Acetone
  • diethyl 2,4,6-trioxoheptanedioate
  • Ethyl 3-oxoglutarate
  • Hydrochloric acid

DownStream

  • 4H-Pyran-4-thione
  • 4H-Thiopyran-4-thione
  • 4-Chloro-2,6-pyridinedicarboxylic acid
  • Dimethyl 4-chloropyridine-2,6-dicarboxylate
  • 4-Chloro-6-(Methoxycarbonyl)picolinic acid
  • 4-Oxoheptanedioic acid
  • 4-Oxo-4H-pyran-2-carboxylic acid
  • 4-hydroxypyridine-2,6-dicarboxylic acid
  • dimethyl 4-hydroxypyridine-2,6-dicarboxylate
  • 1,1,1,3,3-pentabromopropan-2-one

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase.

Biochem. Pharmacol. 34 , 4145-4150, (1985)

Twenty conformationally restricted analogues of glutamate including benzoic acids, hydroxy-benzoic acids, pyridine dicarboxylic acids, and pyran dicarboxylic acids were tested as inhibitors of glutama...

Purification and characterization of dihydrodipicolinate synthase from pea.

Plant Physiol. 98(3) , 813-821., (1992)

Dihydrodipicolinate synthase (EC 4.2.1.52), the first enzyme unique to lysine biosynthesis in bacteria and higher plants, has been purified to homogeneity from etiolated pea (Pisum sativum) seedlings ...

Tracer studies with 13C-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis.

Phytochemistry 57(1) , 33-42, (2001)

The biosynthesis of chelidonic acid was studied in cell suspension cultures of Leucojum aestivum. Cell cultures were supplied with [U-13C]glucose, [l-13C]glucose or [U-13Cs]ribose/ribulose in standard...


More Articles


Related Compounds

  • chelidonic acid
  • chelidonic acid
  • Ammox-chelidonic acid
  • Ammox-chelidonic acid
  • CHELIDONIC ACID 1-HYDRATE
  • Octanethioic acid S-propyl ester
  • benzyl 2,3,4-tri-O-benzyl-D-glucopyranoside
  • 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]oxazol-6-amine
  • 1-(4-Methoxybenzyl)-5-methyl-1,4-diazepane
  • 17-Hydroxy-21-[(1-oxopentyl)oxy]pregna-1,4-diene-3,11,20-trione
  • 5-[(1R)-1-aminoethyl]-2-nitrophenol
  • L-Proline, D-prolyl-
  • 8-(2-Methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
  • 8-Pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
  • 8-Pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
  • [1-(3-Phenylpropyl)cyclobutyl]methanol
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