Oxybuprocaine

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Names

[ CAS No. ]:
99-43-4

[ Name ]:
Oxybuprocaine

[Synonym ]:
Benoxinate
Oxybuprocaine
Oxybucaine
Prescaina
Oxibuprocainum
Conjucain
2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate
4-Amino-3-butoxy-benzoesaeure-(2-diaethylamino-aethylester)
4-amino-3-butoxy-benzoic acid-(2-diethylamino-ethyl ester)
Benoxil
Oxibuprocaina
Oxibuprokain
Oxyriprocaine

Chemical & Physical Properties

[ Density]:
1.052g/cm3

[ Boiling Point ]:
446.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₈N₂O₃

[ Molecular Weight ]:
308.41600

[ Flash Point ]:
224.1ºC

[ Exact Mass ]:
308.21000

[ PSA ]:
64.79000

[ LogP ]:
3.52750

[ Index of Refraction ]:
1.524

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1502000

CHEMICAL NAME :: Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 99-43-4

BEILSTEIN REFERENCE NO. :: 2288926

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H28-N2-O3

MOLECULAR WEIGHT :: 308.47

WISWESSER LINE NOTATION :: 4OR BZ EVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,612,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Butoxy-4-nitrobenzoic acid
2-(Diethylamino)ethanol

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

Oxybuprocaine HCL
Fluorescein / oxybuprocaine
4-((5-(Benzyloxy)-2-bromophenoxy)methyl)pyridine
Methyl 2-((2-methoxy-2-oxoethyl)thio)-1-methyl-1H-imidazole-5-carboxylate
Methyl 1-(2-ethoxy-2-oxoethyl)-2-oxo-1,2-dihydroquinoline-4-carboxylate
5-(4-Carboxybenzyl)-4-oxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylic acid
5-Tert-Butyl 2-Ethyl 4-Oxo-6,7-Dihydropyrazolo[1,5-A]Pyrazine-2,5(4H)-Dicarboxylate
5-Chloro-2,4-bis(methylthio)thiazole
(S)-4-(2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)-3-oxopropyl)benzoic acid
3,4,5,6-Tetrahydro-2H-benzo[4,5]imidazo[2,1-b][1,3,6]oxadiazocine
2-(4-(Allylamino)-2-chloro-5-nitrophenyl)acetic acid
5-(Carboxymethyl)-4-oxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylic acid