(-)-Carveol

Names

[ CAS No. ]:
99-48-9

[ Name ]:
(-)-Carveol

[Synonym ]:
MFCD00869995
EINECS 202-757-4
(-)-Carveol
1-Methyl-4-isopropenyl-6-cyclohexen-2-ol
(5R)-5-Isopropenyl-2-methyl-2-cyclohexen-1-ol
2-Cyclohexen-1-ol, 2-methyl-5-(1-methylethenyl)-, (5R)-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
231.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₆O

[ Molecular Weight ]:
152.233

[ Flash Point ]:
98.3±0.0 °C

[ Exact Mass ]:
152.120117

[ PSA ]:
20.23000

[ LogP ]:
2.55

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.498

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Partly soluble in water. Soluble in alcohol, ethanol and DMSO.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8400000

CHEMICAL NAME :: p-Mentha-6,8-dien-2-ol

CAS REGISTRY NUMBER :: 99-48-9

BEILSTEIN REFERENCE NO. :: 1861032

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H16-O

MOLECULAR WEIGHT :: 152.26

WISWESSER LINE NOTATION :: L6UTJ AQ B1 EY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1055,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 11,1055,1973

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
OS8400000

[ HS Code ]:
2906199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

limonene
DL-carvone
carvyl acetate
2-Cyclohexen-1-one,2-methyl-5-(1-methylethenyl)-, oxime
3-Oxatricyclo[4.1.1.02,4]octane,2,7,7-trimethyl-
(+)-limonene oxide
(+)-alpha-Pinene
(4S,6R)-6-chloro-1-methyl-4-prop-1-en-2-ylcyclohexene
6-chloro-p-mentha-1,8-diene
(+)-Limonene

DownStream

DL-carvone
(Z)-carvone-5,6-oxide
(E)-carveol
carvyl acetate
Acetamido-6-p-menthadien-1.8 (cis)
(-)-carvyl propionate
L(-)-Carvone
(1R,2R,4S,6S)-1-methyl-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-2-ol
(1S,2R,4S,6R)-1-methyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]heptan-2-ol
(1S,2R,5R)-2-Methyl-5-isopropenylcyclohexanol

Customs

[ HS Code ]: 2906199090

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

Chemical composition and larvicidal activity of essential oil from Mentha spicata (Linn.) against three mosquito species.

Parasitol. Res. 110(5) , 2023-32, (2012)

Mosquitoes are blood-feeding insects and serve as the most important vectors for spreading human diseases such as malaria, yellow fever, dengue fever, and filariasis. The continued use of synthetic in...

A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua.

Phytochemistry 71(11-12) , 1264-9, (2010)

The major components of the isoprenoid-rich essential oil of Artemisia annua L. accumulate in the subcuticular sac of glandular secretory trichomes. As part of an effort to understand isoprenoid biosy...