2-Methyl-5-nitroaniline

Suppliers

Names

[ CAS No. ]:
99-55-8

[ Name ]:
2-Methyl-5-nitroaniline

[Synonym ]:
Benzenamine, 2-methyl-5-nitro-
EINECS 202-765-8
5-Nitro-o-toluidine
2-methyl-5-nitrophenylamine
2-Methyl-5-nitrobenzolamin
PNOT
2-Methyl-5-nitroaniline
ScarletbaseG
2-Amino-4-nitrotoluene
devolscarletb
2-Amino-1-methyl-4-nitrobenzene
4-nitro-2-amino-toluene
fastscarletg
2-Methyl-5-nitrobenzenamine
ZR B1 ENW
MFCD00007741

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
329.4±22.0 °C at 760 mmHg

[ Melting Point ]:
103-106 °C(lit.)

[ Molecular Formula ]:
C₇H₈N₂O₂

[ Molecular Weight ]:
152.151

[ Flash Point ]:
153.0±22.3 °C

[ Exact Mass ]:
152.058578

[ PSA ]:
71.84000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.616

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids, chloroformates.

[ Water Solubility ]:
<0.1 g/100 mL at 19 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XU8225000

CHEMICAL NAME :: o-Toluidine, 5-nitro-

CAS REGISTRY NUMBER :: 99-55-8

BEILSTEIN REFERENCE NO. :: 0879021

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H8-N2-O2

MOLECULAR WEIGHT :: 152.17

WISWESSER LINE NOTATION :: ZR B1 ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 160 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12,21,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,169,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,169,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1540 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 13741 (estimated) No. of Female Employees: 12621 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H351-H412

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23/24/25;R40;R52/53

[ Safety Phrases ]:
S36/37-S45-S61

[ RIDADR ]:
UN 2660 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
XU8225000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921430090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Bromo-4-nitrotoluene
o-Toluidine
Methanol
carbon monoxide
2,4-Dinitrotoluene
Benzoic acid, 4-amino-5-methyl-2-nitro- (9CI)
N,N-dimethyl-N'-(2-methyl-5-nitrophenyl)methanimidamide
O-ACETOTOLUIDIDE
2,4-Diaminotoluene
Toluene

DownStream

2-Chloro-N-(2-methyl-5-nitrophenyl)acetamide
2-Methyl-5-nitrophenol
6-Nitroindazole
5'-Amino-2'-methylacetanilide
4-Chloromethyl-n-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
4-methyl-N-(2-methyl-5-nitrophenyl)benzenesulfonamide
Acetamide,N-(2-methyl-5-nitrophenyl)-
5-Amino-2-methylphenol
2,4-Diaminotoluene
2-Chloro-4-nitrobenzoic acid

Customs

[ HS Code ]: 2921430090

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

5-Nitro-ortho-toluidine.

IARC Monogr. Eval. Carcinog. Risks Hum. 48 , 169-77, (1990)

Liver dysfunction among workers handling 5-nitro-o-toluidine.

Gut 50(2) , 266-70, (2002)

5-Nitro-o-toluidine is an aromatic nitro amino compound. While other aromatic compounds are known to damage the human liver and are registered as toxic substances, toxicity information concerning 5-ni...

Establishment of an extraction method for the recovery of tattoo pigments from human skin using HPLC diode array detector technology.

Anal. Chem. 78(18) , 6440-7, (2006)

Tattooing is a widespread process of puncturing pigments into skin, whereas the resulting concentration inside the skin remains unknown. Many tattoo colorants are organic pigments, such as azo pigment...