2-Amino-4-nitrophenol

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Names

[ CAS No. ]:
99-57-0

[ Name ]:
2-Amino-4-nitrophenol

[Synonym ]:
5-nitro 2-hydroxy aniline
2-amino-4-nitro-phenol
EINECS 202-767-9
2-Hydroxy-5-nitroaniline
rodol42
p-nitroaminofenol
2-Amino-1-hydroxy-4-nitrobenzene
1-amino-3-nitro-6-hydroxybenzene
Phenol, 2-amino-4-nitro-
4-nitro-2-amino-1-hydroxybenzene
1-amino-2-hydroxy-5-nitrobenzene
3-amino-4-hydroxynitrobenzene
4-nitro-2-aminofenol
4-NAP
1-hydroxy-2-amino-4-nitrobenzene
2-Amino-4-nitrophenol
Ursol 4GL
MFCD00007695
ZR BQ ENW
2-amino-4-nitrofenol

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
368.1±32.0 °C at 760 mmHg

[ Melting Point ]:
140-143 °C(lit.)

[ Molecular Formula ]:
C6H6N2O3

[ Molecular Weight ]:
154.123

[ Flash Point ]:
176.4±25.1 °C

[ Exact Mass ]:
154.037842

[ PSA ]:
92.07000

[ LogP ]:
1.23

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.689

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ6300000
CHEMICAL NAME :
Phenol, 2-amino-4-nitro-
CAS REGISTRY NUMBER :
99-57-0
BEILSTEIN REFERENCE NO. :
0776533
LAST UPDATED :
199710
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C6-H6-N2-O3
MOLECULAR WEIGHT :
154.14
WISWESSER LINE NOTATION :
ZR BQ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
246 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
143 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13750 mg/kg/15D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32500 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13750 mg/kg/15D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
64375 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
5 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-339,1988 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,167,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,167,1993 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,167,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0280 No. of Facilities: 2232 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 20256 (estimated) No. of Female Employees: 17049 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R36/37/38;R40;R43;R68

[ Safety Phrases ]:
S26-S45-S36/37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
2

[ RTECS ]:
SJ6300000

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2,4-Dinitrophenol
  • aminophenol
  • 2-azido-4-nitrophenol
  • 1,2-Diamino-4-nitrobenzene
  • 4-Nitroanisole
  • 2-Fluoro-5-nitroaniline
  • 2-methylbenzoxazole
  • o-Nitrophenol
  • 3-nitrophenyl azide
  • Water

DownStream

  • 3-amino-6-nitro-1,4-benzoxazin-2-one
  • 2-Chloro-N-(2-hydroxy-5-nitrophenyl)acetamide
  • 2-METHYL-5-NITROBENZO[D]OXAZOLE
  • Bis(2-benzyloxy-3-nitrophenyl)disulfide
  • Nitroxoline
  • 2-(Chloromethyl)-6-nitro-1,3-benzoxazole
  • 2-(2-HYDROXYETHYL)-6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE
  • 5-Nitrobenzo[d]oxazole-2(3H)-thione
  • 2-Chloro-4-nitrophenol
  • 5-Amino-benzooxazole-2-thiol

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • 2-Amino-4-nitrophenol sulfate
  • Sodium 2-amino-4-nitrophenolate
  • 2-amino-4-nitrophenol,hydrochloride
  • 2-Amino-4-nitrophenol-6-sulfonic acid
  • sodium,3-amino-2-hydroxy-5-nitrobenzenesulfonate,2-amino-4-nitrophenol,benzene-1,3-diol,iron,sodium
  • N-(2-hydroxy-5-nitrophenyl)-4-methylbenzenesulfonamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • 1-(2-Chloro-4-fluorobenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine