Lymecycline

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Names

[ CAS No. ]:
992-21-2

[ Name ]:
Lymecycline

[Synonym ]:
limecycline
[(1r,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2r,3s)-2,3-dihydroxy-2-isopropylbutanoate
2,3-Dihydroxy-2-(1-methylethyl)-butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester
lycopsamine
(+)-Indicine

Chemical & Physical Properties

[ Density]:
1.53

[ Boiling Point ]:
840.5ºC at 760 mmHg

[ Melting Point ]:
192.5°C

[ Molecular Formula ]:
C₂₉H₃₈N₄O₁₀

[ Molecular Weight ]:
602.63

[ Flash Point ]:
462.1ºC

[ Exact Mass ]:
602.25900

[ PSA ]:
242.98000

[ LogP ]:
1.02790

[ Index of Refraction ]:
1.693

[ Water Solubility ]:
Very soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL5615000

CHEMICAL NAME :: Lysine, N(sup 6)-((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro -3,6,10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxa mido)methyl)-, (+)-

CAS REGISTRY NUMBER :: 992-21-2

LAST UPDATED :: 199201

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H38-N4-O10

MOLECULAR WEIGHT :: 602.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,333,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 253 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,106,1964