Venlafaxine hydrochloride

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Names

[ CAS No. ]:
99300-78-4

[ Name ]:
Venlafaxine hydrochloride

[Synonym ]:
1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride (1:1)
Efectin
Venlafaxine Hydrochloride
Effexor
Venlafaxine HCl
MFCD03658865
EINECS 200-659-6
Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1)
Efexor
(±)-1-(a-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride
cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride
RTECS GV​8872760

Chemical & Physical Properties

[ Density]:
1.394 g/cm3

[ Boiling Point ]:
397.6ºC at 760 mmHg

[ Melting Point ]:
207-209ºC

[ Molecular Formula ]:
C17H28ClNO2

[ Molecular Weight ]:
313.863

[ Flash Point ]:
194.2ºC

[ Exact Mass ]:
313.180847

[ PSA ]:
32.70000

[ LogP ]:
3.83760

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GV8872760
CHEMICAL NAME :
Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride
CAS REGISTRY NUMBER :
99300-78-4
LAST UPDATED :
199801
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H27-N-O2.Cl-H
MOLECULAR WEIGHT :
313.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
235 mg/kg/12D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes
REFERENCE :
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 20,266,1996

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
1230.0

[ RTECS ]:
GV8872760

[ Hazard Class ]:
3、6.1

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • Venlafaxine
  • 1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydrochloride
  • 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride
  • Formic Acid
  • 1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol
  • Cyclohexanone
  • (4-Methoxyphenyl)acetonitrile

DownStream

  • O-Desmethylvenlafaxine
  • Venlafaxine
  • WY 45233 succinate

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • Desvenlafaxine hydrochloride
  • spiro-venlafaxine hydrochloride
  • didesmethylvenlafaxine hydrochloride
  • D,L-N,N-Didesmethyl-O-desmethyl Venlafaxine Hydrochloride
  • Venlafaxine-d10 hydrochloride
  • venlafaxine besylate
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