Venlafaxine hydrochloride

Suppliers

Names

[ Name ]:
Venlafaxine hydrochloride

[Synonym ]:
1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride (1:1)
Efectin
Venlafaxine Hydrochloride
Effexor
Venlafaxine HCl
MFCD03658865
EINECS 200-659-6
Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1)
Efexor
(±)-1-(a-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride
cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride
RTECS GV8872760

Chemical & Physical Properties

[ Density]:
1.394 g/cm3

[ Boiling Point ]:
397.6ºC at 760 mmHg

[ Melting Point ]:
207-209ºC

[ Molecular Formula ]:
C₁₇H₂₈ClNO₂

[ Molecular Weight ]:
313.863

[ Flash Point ]:
194.2ºC

[ Exact Mass ]:
313.180847

[ PSA ]:
32.70000

[ LogP ]:
3.83760

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV8872760

CHEMICAL NAME :: Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 99300-78-4

LAST UPDATED :: 199801

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H27-N-O2.Cl-H

MOLECULAR WEIGHT :: 313.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 235 mg/kg/12D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :: JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 20,266,1996

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
1230.0

[ RTECS ]:
GV8872760

[ Hazard Class ]:
3、6.1

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Formaldehyde
Venlafaxine
1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydrochloride
1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride
Formic Acid
1-[Cyano-(p-methoxyphenyl)methyl]cyclohexanol
Cyclohexanone
(4-Methoxyphenyl)acetonitrile

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.

J. Chromatogr. A. 1418 , 140-9, (2015)

The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of...

The antidepressant venlafaxine disrupts brain monoamine levels and neuroendocrine responses to stress in rainbow trout.

Environ. Sci. Technol. 48(22) , 13434-42, (2014)

Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is a widely prescribed antidepressant drug routinely detected in the aquatic environment. However, little is known about its impact on the p...

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1363 , 226-235, (2014)

The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method ...