AVN-101 hydrochloride
Modify Date: 2024-02-13 16:06:52
AVN-101 hydrochloride structure
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Common Name | AVN-101 hydrochloride | ||
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| CAS Number | 1061354-48-0 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AVN-101 hydrochlorideAVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1]. |
| Name | AVN-101 |
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| Description | AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1]. |
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| Related Catalog | |
| Target |
5-HT7 Receptor:0.153 nM (Ki) 5-HT2C Receptor:1.17 nM (Ki) 5-HT2A Receptor:1.56 nM (Ki) 5-HT6 Receptor:2.04 nM (Ki) 5-HT2B Receptor:10.6 nM (Ki) 5-HT1A Receptor:61 nM (Ki) 5-HT1B Receptor:720 nM (Ki) H1 Receptor:0.58 nM (Ki) Alpha-2B adrenergic receptor:0.41 nM (Ki) Alpha-2A adrenergic receptor:1.77 nM (Ki) Alpha-2C adrenergic receptor:3.55 nM (Ki) Alpha-1B adrenergic receptor:9.4 nM (Ki) Alpha-1A adrenergic receptor:18.9 nM (Ki) Alpha-1D adrenergic receptor:30.2 nM (Ki) |
| References |
| No Any Chemical & Physical Properties |