Ethosuximide-d3

Modify Date: 2024-01-10 02:35:03

Ethosuximide-d3 Structure
Ethosuximide-d3 structure
Common Name Ethosuximide-d3
CAS Number 1189703-33-0 Molecular Weight 144.18600
Density N/A Boiling Point N/A
Molecular Formula C7H8D3NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ethosuximide-d3


Ethosuximide-d3 is the deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel[1][2].

 Names

Name 3-methyl-3-(2,2,2-trideuterioethyl)pyrrolidine-2,5-dione
Synonym More Synonyms

 Ethosuximide-d3 Biological Activity

Description Ethosuximide-d3 is the deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.

[3]. Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8.

 Chemical & Physical Properties

Molecular Formula C7H8D3NO2
Molecular Weight 144.18600
Exact Mass 144.09800
PSA 49.66000
LogP 0.72510

 Synonyms

Succimitin-d3
Simatin-d3
Etosuximid-d3
Capitus-d3
Atysmal-d3
Ethosuximide-d3
Succimal-d3
Suxilep-d3
Emeside-d3