Nafcillin-d5 sodium

Modify Date: 2024-01-08 15:49:51

Nafcillin-d5 sodium structure	Common Name	Nafcillin-d5 sodium
	CAS Number	1356354-25-0	Molecular Weight	441.487
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₆D₅N₂NaO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nafcillin-d5 sodium

Nafcillin-d5 sodium is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections[1][2].

Name	Sodium (2S,5R,6R)-6-({2-[(2H5)ethyloxy]-1-naphthoyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Synonym	More Synonyms

Description	Nafcillin-d5 sodium is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections[1][2].
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6. [3]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31. [4]. Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51(5): 1787-1794.

Molecular Formula	C₂₁H₁₆D₅N₂NaO₅S
Molecular Weight	441.487
Exact Mass	441.138275

Sodium (2S,5R,6R)-6-({2-[(2H5)ethyloxy]-1-naphthoyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[2-(ethyl-d5-oxy)-1-naphthalenyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, (2S,5R,6R)- (1:1)

Nafcillin-d5 sodium

Use of Nafcillin-d5 sodium

Names

Nafcillin-d5 sodium Biological Activity

Chemical & Physical Properties

Synonyms