L162389
Modify Date: 2024-02-28 17:51:49
L162389 structure
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Common Name | L162389 | ||
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| CAS Number | 169281-53-2 | Molecular Weight | 562.723 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C31H38N4O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of L162389L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM. |
| Name | L162389 |
|---|---|
| Synonym | More Synonyms |
| Description | L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM. |
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| Related Catalog | |
| Target |
Ki: 28 nM (angiotensin AT1 receptor)[1] |
| In Vitro | L-162,389 stimulates phosphatidylinositol turnover, albeit only to a small percentage of the angiotensin response. L-162,389 acts as angiotensin antagonist with IC50 value of 105 nM[1]. |
| Kinase Assay | Monoiodinated 125I-[Sar1,Leu8]angiotensin II is prepared by the Iodo-Gen method. One day after transfection and 24 hr before the binding experiments, the transfected cells are transferred to 6-, 12-, or 24-well culture plates, with 0.15-9 × 105 cells/well, with a goal of total binding of 5-10% of the radiolabeled peptide. The cells are washed twice with buffer (25 mM Tris, 5 mM MgCl2, 140 mM NaCl, pH 7.4) before and after the binding. The binding is carried out for 24 hr at 4°C with 50 pm 125I-[Sar1,Leu8]angiotensin II and variable amounts of unlabeled nonpeptide or peptide ligands in 0.5-1 mL of a 25 mM Tris buffer containing 5 mm MgCl2, pH 7.4. The binding data are analyzed by computerized nonlinear regression analysis using InPlot 4.0. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C31H38N4O4S |
| Molecular Weight | 562.723 |
| Exact Mass | 562.261353 |
| LogP | 7.38 |
| Index of Refraction | 1.607 |
| Storage condition | 2-8℃ |
| butyl ({4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-5-propylbiphenyl-2-yl}sulfonyl)carbamate |
| Butyl ({4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-5-propyl-2-biphenylyl}sulfonyl)carbamate |
| Carbamic acid, N-[[4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-5-propyl[1,1'-biphenyl]-2-yl]sulfonyl]-, butyl ester |