(Rac)-Monepantel sulfone-d5

Modify Date: 2024-04-11 11:25:04

(Rac)-Monepantel sulfone-d5 Structure
(Rac)-Monepantel sulfone-d5 structure
Common Name (Rac)-Monepantel sulfone-d5
CAS Number 2747918-68-7 Molecular Weight 510.42
Density N/A Boiling Point N/A
Molecular Formula C20H8D5F6N3O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Rac)-Monepantel sulfone-d5


(Rac)-Monepantel sulfone-d5 is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.

 Names

Name (Rac)-Monepantel sulfone-d5

 (Rac)-Monepantel sulfone-d5 Biological Activity

Description (Rac)-Monepantel sulfone-d5 is deuterium labeled Monepantel. Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hess J, et al. Assessment of the nematocidal activity of metallocenyl analogues of monepantel. Dalton Trans. 2016 Nov 28;45(44):17662-17671

[3]. Bahrami F, et al. Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway. Am J Cancer Res. 2014 Sep 6;4(5):558-71.

[4]. Raza A, et al. Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro. Parasit Vectors. 2016 Sep 29;9(1):522.

[5]. Stuchlikova, et al. Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo. Chem Biol Interact. 2015 Feb 5;227:63-8. ?

 Chemical & Physical Properties

Molecular Formula C20H8D5F6N3O4S
Molecular Weight 510.42