dimethindene

Modify Date: 2024-01-02 12:44:42

dimethindene Structure
dimethindene structure
Common Name dimethindene
CAS Number 5636-83-9 Molecular Weight 292.41800
Density 1.065 g/cm3 Boiling Point 416.3ºC at 760 mmHg
Molecular Formula C20H24N2 Melting Point 50 - 53 °C
MSDS N/A Flash Point 205.6ºC

 Use of dimethindene


Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

 Names

Name N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
Synonym More Synonyms

 dimethindene Biological Activity

Description Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].
In Vivo Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1]. Animal Model: C57BL/6 mice with skin WH[1] Dosage: 0.25 mg Administration: intraperitoneal injection; once Result: Delayed skin wound closure as compared to vehicle treated mice.

 Chemical & Physical Properties

Density 1.065 g/cm3
Boiling Point 416.3ºC at 760 mmHg
Melting Point 50 - 53 °C
Molecular Formula C20H24N2
Molecular Weight 292.41800
Flash Point 205.6ºC
Exact Mass 292.19400
PSA 16.13000
LogP 4.14670
Index of Refraction 1.587
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT0800000
CHEMICAL NAME :
Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-
CAS REGISTRY NUMBER :
5636-83-9
BEILSTEIN REFERENCE NO. :
0489974
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H24-N2
MOLECULAR WEIGHT :
292.46
WISWESSER LINE NOTATION :
L56 BHJ C2N1&1 DY1&- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
618 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
888 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

Triten
Dimethpyrindene
Dimetindeno
N,N-dimethyl-3-[1-(2-pyridyl)ethyl]inden-2-ethylamine
Dimetindene
dimethyl-{2-[3-(1-pyridin-2-yl-ethyl)-inden-2-yl]-ethyl}-amine
Pecofenil
dimethindene
Dimetindenum
Foristal
Fenistil
Forhistal