3’-O-Methyluridine

Modify Date: 2024-01-12 16:41:17

3’-O-Methyluridine Structure
3’-O-Methyluridine structure
Common Name 3’-O-Methyluridine
CAS Number 6038-59-1 Molecular Weight 258.23
Density 1.53g/cm3 Boiling Point N/A
Molecular Formula C10H14N2O6 Melting Point N/A
MSDS USA Flash Point N/A

 Use of 3’-O-Methyluridine


3’-O-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 4-[1-[(2-methylphenyl)methyl]benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
Synonym More Synonyms

 3’-O-Methyluridine Biological Activity

Description 3’-O-Methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.53g/cm3
Molecular Formula C10H14N2O6
Molecular Weight 258.23
Exact Mass 258.08500
PSA 113.78000
Index of Refraction 1.611

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synthetic Route

~99%

3’-O-Methyluridine Structure

3’-O-Methyluridine

CAS#:6038-59-1

Literature: Aleiwi, Bilal A.; Kurosu, Michio Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3758 - 3762

~83%

3’-O-Methyluridine Structure

3’-O-Methyluridine

CAS#:6038-59-1

Literature: Cramer, Hagen; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2114 - 2136

~%

3’-O-Methyluridine Structure

3’-O-Methyluridine

CAS#:6038-59-1

Literature: Heikkilae, Jarmo; Bjoerkman, Sven; Oeberg, Bo; Chattopadhyaya, Jyoti Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 10 p. 715 - 718

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles1

More Articles
Differentiation of 2'-O- and 3'-O-methylated ribonucleosides by tandem mass spectrometry.

J. Am. Soc. Mass Spectrom. 17 , 1096-1099, (2006)

Recent studies revealed that the 3'-terminal nucleotides in plant microRNAs were methylated on the ribose at the 2' or 3' hydroxyl groups. Here we examined the fragmentation of the electrospray-produc...

 Synonyms

3'-O-Methyl-uridin
O3'-methyl-uridine
3'-O-methyluridine
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