CGP11952

Modify Date: 2024-02-15 09:33:02

CGP11952 Structure
CGP11952 structure
Common Name CGP11952
CAS Number 64078-09-7 Molecular Weight 446.33000
Density 1.34g/cm3 Boiling Point N/A
Molecular Formula C21H21Cl2N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CGP11952


CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.

 Names

Name 1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-5-[(dimethylamino)methyl]-N-ethyl-1,2,4-triazole-3-carboxamide
Synonym More Synonyms

 CGP11952 Biological Activity

Description CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.
Related Catalog
Target

Benzodiazepine[2]

In Vitro CGP11952 (CGP 11952) is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action[1]. The effects of CGP11952 (CGP 11.952), a triazolyl Benzophenone, on cognitive functioning are assessed by means of a computerized neuropsychological battery. In the first study CGP11952 turns out to have a positive effect on information processing speed, perceptual sensitivity and preciseness of responses. Negative effects are found on reaction time. In the second study this latter effect is less clear. A striking result is the less negative effect on memory consolidation under influence of CGP11952 in comparison with other benzodiazepines[2].
References

[1]. Van Wieringen A, et al. Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies. Epilepsy Res. 1987 Jan;1(1):3-15.

[2]. Alpherts WC, et al. CGP 11.952: an experimental benzodiazepine derivative. Effects on cognitive functioning in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):673-82.

 Chemical & Physical Properties

Density 1.34g/cm3
Molecular Formula C21H21Cl2N5O2
Molecular Weight 446.33000
Exact Mass 445.10700
PSA 80.12000
LogP 4.00730
Index of Refraction 1.638
Storage condition 2-8℃

 Synonyms

CGP11952
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