FEBS Letters 2015-03-12

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.

Ashleigh M Byrne, Christina Elliott, Ralf Hoffmann, George S Baillie

文献索引：FEBS Lett. 589(6) , 750-5, (2015)

全文：HTML全文

摘要

The cyclic AMP phosphodiesterases type 4 (PDE4s) are expressed in a cell specific manner, with intracellular targeting directed by unique N-terminal anchor domains. All long form PDE4s are phosphorylated and activated by PKA phosphorylation within their upstream conserved region 1 (UCR1). Here, we identify and characterise a novel PKA site (serine 42) within the N-terminal region of PDE4D7, an isoform whose activity is known to be important in prostate cancer progression and ischemic stroke. In contrast to the UCR1 site, PKA phosphorylation of the PDE4D7 N-terminus appears to occur constitutively and inhibits PDE4 activity to allow cAMP signalling under basal conditions. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

相关化合物

  • 甘油
  • 氟化钠
  • 氯化钠
  • 佛司可林
  • 氯化镁
  • 无水氯化钙
  • 4-羟乙基哌嗪乙磺酸
  • 氯化钠-35cl
  • 谷胱甘肽/5-L-谷氨...
  • 腺苷

相关文献：

Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6.

2014-08-01

[Mol. Plant 7(8) , 1365-83, (2014)]

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

2014-06-02

[J. Exp. Med. 211(6) , 1079-91, (2014)]

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans.

2012-07-01

[Int. J. Obes. 38(12) , 1538-44, (2014)]

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

2014-01-01

[PLoS Biol. 12(1) , e1001758, (2014)]

Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.

2014-12-11

[Oncogene 33(50) , 5688-96, (2014)]

更多文献...