FEBS Letters 2014-12-20

Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.

Katrin Kemmerer, Julia E Weigand

文献索引：FEBS Lett. 588(24) , 4784-90, (2014)

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摘要

The MYC-MAX-MXD network is involved in the regulation of cell differentiation and proliferation. Hypoxia affects the expression levels of several members of this network, but changes specific to MAX expression have so far not been shown. We found that in endothelial cells, hypoxia induces alternative splicing of MAX, thereby increasing the expression of two MAX isoforms that differ from the wild type in their 3' end. Isoform C is degraded by nonsense-mediated decay and isoform E encodes a highly unstable protein. The instability of isoform E is conferred by 36 isoform-specific amino acids, which have the capacity to destabilize heterologous proteins. Both splicing events are therefore unproductive and serve the purpose to downregulate the wild type protein. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

相关化合物

  • 甘油
  • 氯化钠
  • 亚精胺
  • 丙酮酸钠
  • 甲醛
  • 抗坏血酸
  • 氯化镁
  • 氯化钠-35cl
  • 乙二胺四乙酸
  • 放线菌酮

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