PLoS ONE 2015-01-01

Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

Lydia Herrmann, Caspar Wiegmann, Annika Arsalan-Werner, Isabel Hilbrich, Carsten Jäger, Katharina Flach, Anne Suttkus, Ingolf Lachmann, Thomas Arendt, Max Holzer

文献索引：PLoS ONE 10(3) , e0119423, (2015)

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摘要

Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. Additionally, the expression of Hook3 is reduced in AD. Modelling of Hook3 deficiency in cultured cells leads to slowing of endosomal transport and increases β-amyloid production. We propose that Hook3 plays a role in pathogenic events exacerbating AD.

相关化合物

  • 甘油
  • 氟化钠
  • 盐酸
  • 氯化钠
  • 乙醇
  • 4-(2-氨乙基)苯磺酰...
  • 过氧化氢
  • L-谷氨酰胺
  • 邻苯二胺(OPD)
  • 3,3'-二氨基联苯胺

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