Chemical & Pharmaceutical Bulletin 2015-01-01

Novel Dammarane-Type Triterpene Saponins from Panax ginseng Root.

Dong Gu Lee, Ah Young Lee, Kyung-Tack Kim, Eun Ju Cho, Sanghyun Lee

文献索引：Chem. Pharm. Bull. 63 , 927-34, (2015)

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摘要

Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3 (2), ginsenoside-Rs11 (3), and ginsenoside-Re7 (4) based on spectral data. Compounds 1-4 from P. ginseng root were new compounds from nature. They showed good hydroxyl radical scavenging activity and anti-bacterial activity against Escherichia coli and Staphylococcus aureus. However, they did not show any anti-inflammatory activity. In addition, they inhibited the growth of adenocarcinoma gastric stomach cells. Among them, ginsenoside-Rs11 (3) showed the best anti-oxidative, anti-bacterial, and anti-cancer activities.

相关化合物

  • 硫酸
  • 蔗糖
  • 乙腈
  • 过氧化氢
  • 三甲基镓
  • 戊二酸
  • 2,2-联苯基-1-苦基...
  • 二甲基亚砜
  • 1,1-二苯基-2-苦味...
  • 2-脱氧-D-核糖

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