Journal of Medicinal Food 2015-04-01

Neuroprotective effect of prenylated arylbenzofuran and flavonoids from morus alba fruits on glutamate-induced oxidative injury in HT22 hippocampal cells.

Kyeong-Hwa Seo, Dae-Young Lee, Rak-Hun Jeong, Dong-Sung Lee, Young-Eon Kim, Eock-Kee Hong, Youn-Chul Kim, Nam-In Baek

文献索引:J. Med. Food 18(4) , 403-8, (2015)

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摘要

A prenylated arylbenzofuran and six flavonoids were isolated from the fruits of Morus alba L. through silica gel, octadecyl silica gel, and Diaion HP-20 column chromatography. Based on the nuclear magnetic resonance, mass spectrometry, and infrared spectroscopic data, the chemical structures of the compounds were determined to be artoindonesianin O (1), isobavachalcone (2), morachalcone A (3), quercetin (4), astragalin (5), isoquercetin (6), and rutin (7). The isolated compounds were evaluated for protection of HT22-immortalized hippocampal cells against glutamate-induced oxidative stress. Compounds 1 and 3 exhibited protective effects with EC(50) values of 19.7±1.2 and 35.5±2.1 μM, respectively. The major compounds 1-3 and 7 were quantified using liquid chromatography/mass spectrometry analysis and were determined to be 1.88±2.1, 1.90±1.8, 0.78±1.5, and 37.29±2.2 mg/kg, respectively, in the ethanol extract of M. alba L. fruits.


相关化合物

  • 硫酸
  • 盐酸
  • 异丙醇
  • 乙醇
  • 乙腈
  • 二甲基亚砜
  • 氯化氢甲醇溶液
  • 噻唑兰
  • 8-辛酰氧基芘-1,3,6...

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