Mutagenesis 2015-07-01

Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine.

Abhishek Basu, Prosenjit Ghosh, Arin Bhattacharjee, Arup Ranjan Patra, Sudin Bhattacharya

文献索引:Mutagenesis 30 , 509-17, (2015)

全文:HTML全文

摘要

Cisplatin (CDDP) is one of the first-line anticancer drugs indicated for use against various form of human malignancies; but, the therapeutic outcome of CDDP chemotherapy is limited due to the development of myelosuppression and genotoxicity which may lead to secondary cancer. Induction of oxidative stress in normal host cells is thought to be responsible for these adverse effects. Therefore, in search of a potential chemoprotectant, an oraganovanadium compound, viz., vanadium(III)-l-cysteine (VC-III) was evaluated against CDDP-induced clastogenicity and cytotoxicity in bone marrow cells of Swiss albino mice. CDDP was administered intraperitoneally (5mg/kg body weight [b.w.]) and VC-III was given by oral gavage (1mg/kg b.w.) in concomitant and pretreatment schedule. The results showed that VC-III administration significantly (P < 0.001) enhanced cell proliferation and inhibited apoptosis in the bone marrow niche indicating recovery of CDDP-induced myelosuppression. VC-III also significantly (P < 0.001) decreased the percentage of chromosomal aberrations, the frequency of micronuclei formation and the extent of DNA damage. The observed antigenotoxic and cytoprotective effect of VC-III was attributed to its attenuation of free radicals status and restoration of oxidised and reduced glutathione levels. These results suggest that VC-III is a potential candidate for future development as a chemoprotective agent against chemotherapy-associated primary and secondary complications. © The Author 2015. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.


相关化合物

  • 溴化乙啶
  • 乙二胺
  • 甲醇
  • 5,5'二硫代双(2-硝...
  • L-半胱氨酸
  • 二苯胺
  • 曲拉通X-100
  • 秋水仙碱
  • 磺胺
  • 哒螨灵

相关文献:

L. monocytogenes in a cheese processing facility: Learning from contamination scenarios over three years of sampling.

2014-10-17

[Int. J. Food Microbiol. 189 , 98-105, (2014)]

Alpha-fetoprotein, identified as a novel marker for the antioxidant effect of placental extract, exhibits synergistic antioxidant activity in the presence of estradiol.

2014-01-01

[PLoS ONE 9(6) , e99421, (2014)]

Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.

2014-04-01

[Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)]

Glucose recognition proteins for glucose sensing at physiological concentrations and temperatures.

2014-07-18

[ACS Chem. Biol. 9(7) , 1595-602, (2014)]

Reservoirs of listeria species in three environmental ecosystems.

2014-09-01

[Appl. Environ. Microbiol. 80(18) , 5583-92, (2014)]

更多文献...