Nature 2014-12-11

Catalytic enantioselective synthesis of quaternary carbon stereocentres.

Kyle W Quasdorf, Larry E Overman

文献索引：Nature 516(7530) , 181-91, (2014)

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摘要

Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoisomers of this important structural motif. Here we discuss the many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.

相关化合物

  • 活性炭
  • 吗啡
  • 吗啡五水硫酸盐
  • 可的松
  • 吗啡硫酸盐甲醇

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