Chirality 2007-08-01

Direct high-performance liquid chromatographic separation of the enantiomers of an aromatic amine and four aminoalcohols using polysaccharide chiral stationary phases and acidic additive.

Salvatore Caccamese, Salvatore Bianca, Guy T Carter

文献索引：Chirality 19(8) , 647-53, (2007)

全文：HTML全文

摘要

The HPLC enantiomeric separation of N-benzyl-alpha-methyl-benzylamine, phenylalaninol, tryptophanol, 2 (diphenylhydroxymethyl)pyrrolidine, and isoproterenol was accomplished in the normal-phase mode using two polysaccharide-derived chiral stationary phases (CSPs) and various n-hexane/2-propanol mobile phases with acidic (TFA) or basic (DEA) additive. The compounds were separated without any derivatization and separation factor range between 2.09 and 1.09 with resolution factor 3.4 and 0.4, respectively. The best separation of the enantiomers of the amine was achieved on amylose tris (3, 5-dimethylphenylcarbamate) CSP with TFA additive in the mobile phase; in acidic conditions, instead, the best enantioseparation of the aminoalcohols was achieved on cellulose tris (3, 5-dimethylphenilcarbamate). A long equilibration time of the CSP when switching from an undoped mobile phase to a doped one is required to obtain reproducible results.

相关化合物

  • L-色氨醇
  • D-苯丙氨醇
  • L-苯丙氨醇

相关文献：

Enantioselective formal synthesis of (+)-dihydrocorynantheine and (-)-dihydrocorynantheol.

2009-02-06

[J. Org. Chem. 74(3) , 1205-11, (2009)]

Straightforward methodology for the enantioselective synthesis of benzo[a]- and indolo[2,3-a]quinolizidines.

2007-07-06

[J. Org. Chem. 72(14) , 5193-201, (2007)]

Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline.

2013-03-07

[Chem. Commun. (Camb.) 49(19) , 1954-6, (2013)]

Tryptophanyl-tRNA synthetase in cell lines resistant to tryptophan analogs.

1991-07-01

[Exp. Cell Res. 195(1) , 66-78, (1991)]

Lambda-carrageenan: a novel chiral selector for capillary electrophoresis.

1996-01-01

[Chirality 8(7) , 503-510, (1996)]

更多文献...