Bioscience, Biotechnology, and Biochemistry 2015-01-01

Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.

Katsumi Shibata, Ryoko Kobayashi, Tsutomu Fukuwatari

文献索引：Biosci. Biotechnol. Biochem. 79(1) , 103-8, (2015)

全文：HTML全文

摘要

The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam is also increased by vitamin B1 deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B1 deficiency or severe food restriction. The present results showed that vitamin B1 deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.

相关化合物

  • 吡啶-2,3-二羧酸
  • L-犬尿氨酸
  • 邻氨基苯甲酸
  • 蔗糖
  • 黄尿酸
  • 犬尿喹啉酸
  • L-蛋氨酸

相关文献：

The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

2015-10-01

[Cell Death Differ. 22 , 1618-29, (2015)]

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.

2015-01-01

[J. Neuroinflammation 12 , 110, (2015)]

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

1994-06-01

[Clin. Chem. 40(6) , 862-6, (1994)]

Chemical genetics reveals a complex functional ground state of neural stem cells.

2007-05-01

[Nat. Chem. Biol. 3(5) , 268-273, (2007)]

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

2009-02-12

[Nature 457(7231) , 910-4, (2009)]

更多文献...