In vitro evaluation of the antimicrobial activity of lichen metabolites as potential preservatives.

K Ingólfsdóttir, S F Bloomfield, P J Hylands

文献索引：Antimicrob. Agents Chemother. 28(2) , 289-92, (1985)

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摘要

Antimicrobial screening of several lichen species and subsequent isolation and structure elucidation of active compounds revealed that the hydrolysis products of certain lichen metabolites, i.e., depsides, were active against gram-negative bacteria and fungi as well as gram-positive bacteria. The active constituents isolated from Stereocaulon alpinum and Peltigera aphthosa were identified, respectively, as methyl beta-orsellinate and a mixture of methyl and ethyl orsellinates. MIC determinations indicated that activity of these compounds was superior to that of the commonly used preservative agents methyl and propyl p-hydroxybenzoates and was of the same order as that of chlorocresol.