ACS Nano 2015-10-27

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.

Lu Zhang, Qiang Feng, Jiuling Wang, Shuai Zhang, Baoquan Ding, Yujie Wei, Mingdong Dong, Ji-Young Ryu, Tae-Young Yoon, Xinghua Shi, Jiashu Sun, Xingyu Jiang

文献索引：ACS Nano 9 , 9912-21, (2015)

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摘要

The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell-particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell-particle interaction may have important implications for designing drug nanocarriers.

相关化合物

  • 连二亚硫酸钠
  • N,N-二甲基甲酰胺
  • 二甲基亚砜
  • 胆固醇
  • 康普瑞丁A4
  • 乙交酯
  • 1,2-二棕榈酰-sn-甘...
  • DL-丙交酯
  • DL-2-氨基丙酸
  • 磷酸乙醇胺

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