Cephalalgia 2011-07-01

The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?

Song Guo, L Vecsei, Messoud Ashina

文献索引：Cephalalgia 31 , 1029-1038, (2011)

全文：HTML全文

摘要

In recent years the kynurenine family of compounds, metabolites of tryptophan, has become an area of intensive research because of its neuroactive properties. Two metabolites of this family have become of interest in relation to migraine and pain processing.Experimental studies have shown that kynurenic acid (KYNA) plays an important role in the transmission of sensory impulses in the trigeminovascular system and that increased levels of KYNA decrease the sensitivity of the cerebral cortex to cortical spreading depression. Furthermore, another metabolite of the kynurenine family, L-kynurenine, exerts vasodilating effects similar to nitric oxide by increasing cyclic guanosine monophosphate.This review summarizes current knowledge of the role of kynurenine signalling in trigeminal and central pain processing, including its therapeutic prospects in migraine treatment.

相关化合物

  • L-犬尿氨酸
  • L-犬尿氨酸硫酸盐

相关文献：

Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.

2015-01-01

[Biosci. Biotechnol. Biochem. 79(1) , 103-8, (2015)]

The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.

2014-01-01

[J. Nutr. Sci. Vitaminol. 60(4) , 261-8, (2014)]

Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.

2014-01-01

[J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015)]

A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.

2015-03-25

[J. Pharm. Biomed. Anal. 107 , 426-31, (2015)]

Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.

2015-02-03

[J. Ethnopharmacol. 160 , 86-93, (2014)]

更多文献...