Natural product communications 2015-07-01

New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties.

Ekaterina K Ogurtsova, Tatyana N Makarieva, Yuliya V Korolkova, Yaroslav A Andreev, Irina V Mosharova, Vladimir A Denisenko, Pavel S Dmitrenok, Yeon-Ju Lee, Eugene V Grishin, Valentin A Stonik

文献索引：Nat. Prod. Commun. 10 , 1171-3, (2015)

全文：HTML全文

摘要

The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra, and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 μM, respectively. Hexadecylguanidine (3) was not active against these receptors.

相关化合物

  • 十六胺
  • 1H-吡唑-1-甲脒盐酸...

相关文献：

A carbon nanotube/poly [Ni-(Protoporphyrin IX)] composite for amperometric detection of long chain aliphatic amines.

2015-08-01

[Bioelectrochemistry 104 , 51-7, (2015)]

Simple and sensitive progesterone detection in human serum using a CdSe/ZnS quantum dot-based direct binding assay.

2015-08-15

[Anal. Biochem. 483 , 54-61, (2015)]

Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans.

2015-10-01

[Nutrition 31 , 1255-9, (2015)]

Near-Room Temperature Synthesis of Core/Shell-Structured Quantum Dots.

2015-09-01

[J. Nanosci. Nanotechnol. 15 , 7146-52, (2015)]

Solid Solutions of Rare Earth Cations in Mesoporous Anatase Beads and Their Performances in Dye-Sensitized Solar Cells.

2015-01-01

[Sci. Rep. 5 , 16785, (2015)]

更多文献...