Organic & Biomolecular Chemistry 2012-11-21

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.

E Zachary Oblak, Erin S D Bolstad, Sophia N Ononye, Nigel D Priestley, M Kyle Hadden, Dennis L Wright

文献索引：Org. Biomol. Chem. 10(43) , 8597-604, (2012)

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摘要

A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.

相关化合物

  • 桧木醇
  • 呋喃
  • 环庚三烯酚酮

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