Sodium Butyrate Ameliorates L-Arginine-Induced Pancreatitis and Associated Fibrosis in Wistar Rat: Role of Inflammation and Nitrosative Stress.
Gayathri Kanika, Sabbir Khan, Gopabandhu Jena
文献索引:J. Biochem. Mol. Toxicol. 29 , 349-59, (2015)
全文:HTML全文
摘要
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine (L-Arg)-induced pancreatic fibrosis in Wistar rats. Pancreatic fibrosis was induced by twice intraperitoneal (i.p.) injections of 20% L-Arg (250 mg/100 g) at 2-h interval on day 1, 4, 7, and 10, whereas SB (800 mg/kg/day) was administrated for 10 days. At the end of the study, biochemical estimations, histological alterations, DNA damage, and the expression of various proteins were evaluated. Posttreatment of SB decreased L-Arg-induced oxidative and nitrosative stress, DNA damage, histological alterations, and fibrosis. Interestingly, posttreatment of SB significantly decreased the expression of α-smooth muscle actin, interleukin-1β, inducible nitric oxide synthase, and 3-nitrotyrosine. The present study demonstrated that posttreatment of SB alleviates L-Arg-induced pancreatic damage and fibrosis in rat.© 2015 Wiley Periodicals, Inc.
相关化合物
相关文献:
2015-04-01
[Theriogenology 83(6) , 1085-92, (2015)]
2015-09-01
[Hum. Reprod. 30 , 2138-51, (2015)]
2011-03-01
[Viruses 3 , 233-53, (2011)]
2015-02-26
[J. Proteomics 116 , 15-23, (2015)]
2015-01-01
[PLoS ONE 10(3) , e0118652, (2015)]