Chemical Communications 2012-09-18

Total synthesis of ascididemin via anionic cascade ring closure.

Ida Nymann Petersen, François Crestey, Jesper Langgaard Kristensen

文献索引：Chem. Commun. (Camb.) 48(72) , 9092-4, (2012)

全文：HTML全文

摘要

A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.

相关化合物

  • 4-甲基-3-溴吡啶
  • 邻氟苯乙酮

相关文献：

Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.

2004-04-05

[Bioorg. Med. Chem. Lett. 14(7) , 1679-82, (2004)]

Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.

2002-10-21

[Bioorg. Med. Chem. Lett. 12(20) , 3009-13, (2002)]

Condensed heteroaromatic ring systems. XV. Synthesis of pyranopyridinones from halopyridinecarbonitriles. Sakamoto T, et al.

[Chem. Pharm. Bull. 36(5) , 1890-1894, (1988)]

更多文献...