Journal of Enzyme Inhibition and Medicinal Chemistry 2014-12-01

Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity.

Tadashi Hatanaka, Kayoko Kawakami, Misugi Uraji

文献索引：J. Enzyme Inhib. Med. Chem. 29(6) , 823-8, (2014)

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摘要

The collagen tripeptide fragments Gly-Ala-Hyp, Gly-Pro-Ala and Gly-Pro-Hyp were generated by hydrolyzing collagen from pig-skin, cattle-skin, fish-scales and chicken-feet, respectively, with Streptomyces collagenase. Collagenase treatment increased the concentration of tripeptides in the hydrolysates by 13-15% (w/w). Of the three peptides, Gly-Pro-Hyp was a true peptidic inhibitor of dipeptidylpeptidase-IV (DPP-IV), because DPP-IV could not hydrolyze the bond between Pro-Hyp. This tripeptide was a moderately competitive inhibitor (Ki=4.5 mM) of DPP-IV, and its level in the collagen hydrolysates could be greatly increased (4-9% [w/w]) using Streptomyces collagenase.

相关化合物

  • 氯化钠
  • 氯化钠-35cl
  • 甘氨酰-L-脯氨酰-L...
  • 九氟戊酸

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