Refining the pathway of carbide insertion into the nitrogenase M-cluster.
Jared A Wiig, Yilin Hu, Markus W Ribbe
文献索引:Nat. Commun. 6 , 8034, (2015)
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摘要
Carbide insertion plays a pivotal role in the biosynthesis of M-cluster, the cofactor of nitrogenase. Previously, we proposed a carbide insertion pathway involving methyltransfer from SAM to a FeS precursor and hydrogen abstraction from this methyl group that initiates the radical-based precursor maturation. Here we demonstrate that the methyl group is transferred to a precursor-associated sulfur before hydrogen abstraction, thereby refining the initial steps of the carbide insertion pathway.
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