The metabolism of some food additives related to piperonal in the rabbit.
D J Wright, G M Holder
文献索引:Xenobiotica 10(4) , 265-70, (1980)
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摘要
1. The metabolism of piperonylidene acetone, and the food additives piperonyl acetone, piperonyl acetate and piperonyl isobutyrate were studied in male rabbits after oral doses of 100 mg/kg. 2. Both piperonylidene acetone and piperonyl acetone were extensively excreted as 4-(3,4-methylenedioxyphenyl)-butan-2-ol to the extent of 71.5% and 81.5% dose respectively in the three-day urine. 3. The esters, piperonyl acetate and piperonyl isobutyrate, were both metabolized to piperonylic acid, to the extent of 70.5% and 11.4% of dose respectively, in the three-day urine.
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2012-09-01
[Food Chem. Toxicol. 50 Suppl 2 , S358-62, (2012)]