Synthesis of 9-membered dilactams derived from 1,3-diaminopropionic and glutamic acids.
A N Chulin, I L Rodionov, V T Ivanov
文献索引:J. Pept. Res. 63(3) , 235-40, (2004)
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摘要
Previously unknown 9-membered bridged dipeptides derived from l or d isomers of 1,3-diaminopropionic acids and l-glutamic acid were synthesized using aminoacyl incorporation reaction. Key intermediates containing internal pyroglutamyl moiety were prepared via side chain to backbone cyclization of related protected dipeptide derivatives of glutamic acid.
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