Applied Radiation and Isotopes 2015-02-01

Single vial freeze-dried TRODAT-1 kit: preparation and demonstration of clinical efficacy of [(99m)Tc]TRODAT-1 in Indian scenario.

Aruna Korde, Mythili Kameswaran, Drishty Satpati, Haladhar Dev Sarma, Sharmila Banerjee, Ajit Shinto, K K Kamaleshwaran, Grace Samuel

文献索引：Appl. Radiat. Isot. 96 , 57-62, (2014)

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摘要

A single vial freeze-dried kit formulation for preparation of three patients' dose of [(99m)Tc]TRODAT-1 has been developed for early diagnosis of Parkinson's disease (PD). Kits were evaluated to ascertain the purity, stability and batch to batch variations. Preclinical evaluation was carried out in laboratory animals and clinical imaging was performed in human patients with PD. The labeling yield and purity of [(99m)Tc]TRODAT-1 was >90%. Swiss mice showed retention of [(99m)Tc]TRODAT-1 in the mid brain region. Clinical studies showed decreased striatal uptake with increasing severity of PD.Copyright © 2014 Elsevier Ltd. All rights reserved.

相关化合物

  • 乙醇
  • 乙腈
  • 氯化亚锡
  • 乙醇钽(V)

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