International Journal of Pharmaceutics 2014-08-25

Surface charge switching nanoparticles for magnetic resonance imaging.

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

文献索引：Int. J. Pharm. 471(1-2) , 127-34, (2014)

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摘要

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.Copyright © 2014 Elsevier B.V. All rights reserved.

相关化合物

  • 乙醚
  • 正己烷
  • 三光气
  • 月桂酸
  • N,N-二甲基甲酰胺
  • 三氟乙酸(TFA)
  • 二甲基亚砜
  • 正己胺
  • 冰醋酸
  • 吡啶

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