Synthesis and pharmacological evaluation of carvacrol propionate.

Marilia Trindade de Santana, Viviane Barros Silva, Renan Guedes de Brito, Priscila Laíse dos Santos, Sócrates Cabral de Holanda Cavalcanti, Emiliano Oliveira Barreto, Jamylle Nunes de Souza Ferro, Márcio Roberto Viana dos Santos, Adriano Antunes de Sousa Araújo, Lucindo José Quintans-Júnior

文献索引：Inflammation 37(5) , 1575-87, (2014)

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摘要

This study aimed at synthesizing the carvacrol propionate (CP) and evaluating its pharmacological profile. CP was obtained from carvacrol and propionyl chloride through an esterification reaction. Male Swiss mice were treated with CP (25, 50, or 100 mg/kg). We evaluated the analgesic effect, mechanical hyperalgesia, and anti-inflammatory effect. Pre-treatment with CP inhibited (p<0.01 and 0.001) the formalin-induced nociception in both phases. CP inhibited (p<0.05, 0.01, and 0.001) the development of mechanical hyperalgesia. CP was able to decrease the leukocyte recruitment (p<0.001) and the amount of TNF-α (p<0.001), IL-1β (p<0.05), and protein leakage (p<0.01) into the pleural cavity. In addition, the paw edema was inhibited by CP (p<0.05, 0.01, and 0.001). The CP attenuates nociception, mechanical hyperalgesia, and inflammation, through an inhibition of cytokines.