Bioanalysis 2015-10-01

Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling.

Suzanne L Parker, Jason A Roberts, Jeffrey Lipman, Steven C Wallis

文献索引：Bioanalysis 7 , 2585-95, (2015)

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摘要

Fosfomycin is an antibiotic of considerable interest for the treatment of infection by multidrug-resistant bacteria. Translating microsampling techniques into clinical PK studies may provide effective dosing information to improve patient outcomes and minimize the potential development of resistance.Accuracy and precision results were within ±15%; the method was validated across the range of 5-2000 µg/ml of fosfomycin using volumetric absorptive microsampling (VAMS) devices.The VAMS techniques provide acceptable validation data as assessed for lower limit of quantification, linearity, intra- and interday precision and accuracy, selectivity and matrix effects. Results from the recovery and stability studies suggest challenges remain for the analysis of fosfomycin in whole blood using VAMS.

相关化合物

  • 乙酸铵
  • 乙腈
  • 甲醇
  • 乙基磷酸

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