Organic & Biomolecular Chemistry 2012-12-28

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud

文献索引：Org. Biomol. Chem. 10(48) , 9601-19, (2012)

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摘要

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

相关化合物

  • 山梨醇
  • D-葡糖-6-磷酸

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