Journal of chromatography. A 2015-09-11

A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery.

Yutao Jiang, Daniel Hascall, Delia Li, Joseph H Pease

文献索引：J. Chromatogr. A. 1411 , 63-8, (2015)

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摘要

In this paper, we introduce a high throughput LCMS/UV/CAD/CLND system that improves upon previously reported systems by increasing both the quantitation accuracy and the range of compounds amenable to testing, in particular, low molecular weight "fragment" compounds. This system consists of a charged aerosol detector (CAD) and chemiluminescent nitrogen detector (CLND) added to a LCMS/UV system. Our results show that the addition of CAD and CLND to LCMS/UV is more reliable for concentration determination for a wider range of compounds than either detector alone. Our setup also allows for the parallel analysis of each sample by all four detectors and so does not significantly increase run time per sample. Copyright © 2015 Elsevier B.V. All rights reserved.

相关化合物

  • 酮康唑
  • 对乙酰氨基苯酚
  • N,N'-二乙酰基肼
  • 利血平
  • 偶氮苯
  • 苯酚
  • 酮洛芬
  • 茶碱
  • 布洛芬

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