Bioorganic & Medicinal Chemistry 2011-04-01

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage.

Hnin Thanda Aung, Tadashi Furukawa, Toshiaki Nikai, Masatake Niwa, Yoshiaki Takaya

文献索引：Bioorg. Med. Chem. 19 , 2392-6, (2011)

全文：HTML全文

摘要

In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic acid (2) and 3-(3,4-dihydroxyphenyl)lactic acid (3). In this study, we investigated the structural requirements necessary for inhibition of snake venom activity through the use of compounds, which are structurally related to rosmarinic acid (1). By examining anti-hemorrhagic activity of cinnamic acid analogs against Protobothrops flavoviridis (Habu) venom, it was revealed that the presence of the E-enoic acid moiety (-CH=CH-COOH) was critical. Furthermore, among the compound tested, it was concluded that rosmarinic acid (1) (IC(50) 0.15 μM) was the most potent inhibitor against the venom.Copyright © 2011 Elsevier Ltd. All rights reserved.

相关化合物

  • 巴豆酸
  • 绿原酸
  • 山梨酸
  • 咖啡酸
  • 反式对羟基肉桂酸
  • 肉桂醇； beta-苯丙...
  • 反式阿魏酸
  • 肉桂酸甲酯
  • 桂皮醛
  • 肉桂酸甲酯

相关文献：

Identification of the toxic trigger in mushroom poisoning.

2009-07-01

[Nat. Chem. Biol. 5 , 465-7, (2009)]

Chemical renal medullectomy. Effect on urinary prostaglandin E2 and plasma renin in response to variations in sodium intake and in relation to blood pressure.

1983-01-01

[Hypertension 5(6) , 951-7, (1983)]

Using organic acids to control subacute ruminal acidosis and fermentation in feedlot cattle fed a high-grain diet.

2015-08-01

[J. Anim. Sci. 93 , 3950-8, (2015)]

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

2012-12-01

[FASEB J. 26 , 4951-65, (2012)]

Preventive effect of resistant starch on activated carbon-induced constipation in mice.

2013-07-01

[Exp. Ther. Med. 6 , 228-232, (2013)]

更多文献...