Journal of Natural Products 2005-07-01

The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists.

Fang-Rong Chang, Ken-ichiro Hayashi, Nam-Hai Chua, Shuichi Kamio, Zih-You Huang, Hiroshi Nozaki, Yang-Chang Wu

文献索引：J. Nat. Prod. 68 , 971-3, (2005)

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摘要

The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and pure compounds (e.g., 17beta-estradiol (1), genistein (10), and daidzein (11)) and also to distinguish effects of structural changes on activity. Thus, this rapid sensitive system was proven to be suitable for the discovery of natural products with estrogenic activity.

相关化合物

  • 雌二醇
  • 维生素D3
  • β-谷甾醇
  • 黄芩素； 黄芩苷元
  • beta-雌二醇半水合...
  • 木犀草素; 3',4',5,...
  • 染料木素
  • 睾酮
  • 大豆苷元
  • 葛根素

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