Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative.
J P Fernandez, Y Robbe, J P Chapat, J L Chanal, M Genin, H Sentenac-Roumanou, M Fatome
文献索引:J. Med. Chem. 26(9) , 1317-9, (1983)
全文:HTML全文
摘要
Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.
相关化合物
相关文献:
2015-12-15
[Bioorg. Med. Chem. 23 , 7543-64, (2015)]
1990-02-01
[Gig. Sanit. (2) , 69, (1990)]