Journal of the American Chemical Society 2003-10-29

Sequential and specific exchange of multiple coiled-coil components.

Nathan A Schnarr, Alan J Kennan

文献索引：J. Am. Chem. Soc. 125(43) , 13046-51, (2003)

全文：HTML全文

摘要

The capacity for sequential and specific exchange of single peptides from coiled-coil heterotrimers is investigated. Dual hydrophobic-hydrophilic interface systems permit iterative cycles of pH-triggered strand exchange that can specifically replace one, two, or even all three initial trimer components. The resultant new complexes are either resistant to or capable of further exchange. Control experiments demonstrate that background exchange among different complexes is negligible. When triggered, however, selective displacement of the same peptide from only one of two distinct heterotrimers is feasible. Previously documented peptidic cross-linking strategies remain operative in these more intricate environments.

相关化合物

  • D-环己基丙氨酸

相关文献：

Experimental evaluation of CH-π interactions in a protein core.

2012-05-07

[Chemistry 18(19) , 5832-6, (2012)]

Mapping the ligand-binding site on the C5a receptor: arginine74 of C5a contacts aspartate282 of the C5a receptor.

2001-11-20

[Biochemistry 40(46) , 14047-52, (2001)]

Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.

1998-09-29

[Biochemistry 37(39) , 13507-15, (1998)]

Up-regulation of adenosine A1 receptor binding in pentylenetetrazol kindling in mice: effects of angiotensin IV.

2005-01-25

[Brain Res. 1032(1-2) , 94-103, (2005)]

Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease.

2007-08-23

[Neurosci. Lett. 423(3) , 194-9, (2007)]

更多文献...