Organic Letters 2012-08-03

Synthesis of α,α-difluoroethyl aryl and heteroaryl ethers.

Eddie Yang, Matthew R Reese, John M Humphrey

文献索引：Org. Lett. 14(15) , 3944-7, (2012)

全文：HTML全文

摘要

Fluorine plays a critical role in modern medicinal chemistry due to its unique properties, and new methods for its incorporation into target molecules are of high interest. An efficient new method for the preparation of aryl-α,α-difluoroethyl ethers (4) via addition of aryl and heteroaryl alcohols (1) to commercially available 2-bromo-1,1-difluoroethene (2) and subsequent hydrogenolysis is presented. This procedure is an attractive alternative to existing methods that employ harshly reactive fluorinating systems such as xenon difluoride and hydrogen fluoride.

相关化合物

  • 氟化氢
  • 二氟代氙

相关文献：

Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics.

2014-12-01

[Invest. Ophthalmol. Vis. Sci. 55(12) , 8153-62, (2014)]

In vitro antiviral and immunomodulatory activity of arbidol and structurally related derivatives in herpes simplex virus type 1-infected human keratinocytes (HaCat).

2014-11-01

[J. Med. Microbiol. 63(Pt 11) , 1474-83, (2014)]

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.

2015-01-01

[PLoS ONE 10(4) , e0124242, (2015)]

Discovery of optimal zeolites for challenging separations and chemical transformations using predictive materials modeling.

2015-01-01

[Nat. Commun. 6 , 5912, (2015)]

Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes.

2015-01-01

[Stem Cells 33(1) , 301-9, (2014)]

更多文献...