Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy
Sudhir K. Yadav, Biplab Adhikary, Sandip K. Bandyopadhyay, Subrata Chattopadhyay
文献索引:Biochim. Biophys. Acta 1830(6) , 3776-86, (2013)
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摘要
Background The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically.
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