Bioorganic & Medicinal Chemistry Letters 2007-11-15

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

文献索引:Bioorg. Med. Chem. Lett. 17(22) , 6206-11, (2007)

全文:HTML全文

摘要

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.


相关化合物

  • 5-溴-2,4-二氯嘧啶

相关文献:

Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.

2013-12-12

[J. Med. Chem. 56(23) , 9683-92, (2013)]

[Synthesis , 861, (2006)]

Pyrimidines. Part VIII. Halogeno-and hydrazino-pyrimidines. Chesterfield J, et al.

[J. Chem. Soc. , 3478-3481, (1955)]

[Synthesis 5 , 728-734, (2003)]

Synthesis of Various 5-Substituted Uracils. Peters D, et al.

[J. Heterocycl. Chem. 27(7) , 2165-70, (1990)]

更多文献...