Bioorganic & Medicinal Chemistry 2008-01-01

Structure–activity correlations for β-phenethylamines at human trace amine receptor 1

Anita H. Lewin, Hernán A. Navarro, S. Wayne Mascarella, Anita H. Lewin, Hernán A. Navarro, S. Wayne Mascarella

文献索引：Bioorg. Med. Chem. 16 , 7415-23, (2008)

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摘要

CoMFA 3D-QSAR studies on the potency of 68 β-phenethylamine analogs to activate hTAAR 1 (61% steric, 39% electrostatic) indicates that bulk both at nitrogen and 4-aryl leads to lower potency.

相关化合物

  • 3-甲氧基苯乙胺
  • β-苯乙胺
  • (R)-(+)-β-甲基苯乙...
  • (S)-2-苯基-1-丙胺
  • 酪胺
  • 对甲基苯乙胺
  • N-甲基-beta-苯乙胺
  • N,N-二甲基-2-苯乙...

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